Journal of Oral Cancer and Research

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Table of Content: Volume 4, Issue 1

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Research Article Pages 49-56

The Correlation between Clinical and Pathological Lymph Node Status in Oral Squamous Cell Carcinoma

Authors: Evan Roche Rabie and Ciska-Mari Schouwstra

Abstract: The presence of nodal metastasis from OSCC is the single most important prognostic feature. Extranodal extension further decreases survival by approximately half. Clinical evaluation of the nodal basin has been found to correlate poorly with pathological nodal status.

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Research Article Pages 44-48

Influence of Acetaldehyde on Oral Epithelial Cells

Authors: Yuji Miyazaki, Ayako Okuyama, Miyako Hoshino, Michiko Nishimura and Kentaro Kikuchi

Abstract: Acetaldehyde, a product of alcohol metabolism, has been recognized a risk factor for carcinogenesis. To clarify the carcinogenic effects of acetaldehyde in the oral cavity and mechanisms involved, normal oral epithelial cells were incubated with several concentrations of acetaldehyde and assays of genetic and epigenetic changes were performed. Acetaldehyde induced malignant transformation of normal oral epithelial cells and demethylation of the erbB2 gene.

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